In a 2019 study published in the journal Nanotoxicology, researchers recreated the first phase of digestion in mice and fed them titanium dioxide, then examined whether accumulation occurred in the organs. Researchers wrote: “Significant accumulation of titanium was observed in the liver and intestine of E171-fed mice; in the latter a threefold increase in the number of TiO2 particles was also measured. Titanium accumulation in the liver was associated with necroinflammatory foci containing tissue monocytes/macrophages. Three days after the last dose, increased superoxide production and inflammation were observed in the stomach and intestine. Overall, [this] indicates that the risk for human health associated with dietary exposure to E171 needs to be carefully considered.”

Lithopone, a chemical compound with a rich history, emerges as a vital substance in various industries. Comprising barium sulfate and zinc sulfide, this compound boasts unique properties that make it a popular choice in applications such as paints, inks, and plastics. Recognized for its exceptional opacity and brightness, lithopone significantly enhances the covering power of materials in which it is incorporated. Its inert nature and resistance to atmospheric influences contribute to its longevity in diverse formulations. As a white pigment, lithopone plays a pivotal role in achieving vibrant and enduring colors across a spectrum of products, marking it as a cornerstone in the realm of chemical compounds.